(SLE)
TONOGENKONCEL(INNC)
ALLOGENEIC PRIMARY HUMAN CHONDROCYTES TRANSDUCED WITH A RETROVIRAL VECTOR EXPRESSING HUMAN TRANSFORMING GROWTH FACTOR-BETA1 (TGF-BETA1). A MASTER CELL BANK OF PRIMARY HUMAN CHONDROCYTES, GROWN FROM CARTILAGE TISSUE OBTAINED FROM THE SURGICAL EXCISION OF A POLYDACTYLY FINGER FROM A THREE-YEAR-OLD FEMALE DONOR, WAS PREPARED. AFTER TRANSDUCTION OF CELLS FROM THE MASTER CELL BANK, A SINGLE CLONAL POPULATION WAS SELECTED USING LIMITING DILUTION AND SUBMITTED TO IRRADIATION. CELLS EXPRESS TGF-BETA1, TYPE I AND TYPE II COLLAGEN AS WELL AS TYPE I AND TYPE II TGF-BETA1 RECEPTORS; THEY LACK EXPRESSION OF GAG AND POL GENES.(WHOM)
TONOGENCONCELUM(INN)