(INNS)
VALANAFUSP ALFA(INNC)
ANTI-(HUMAN INSULIN RECEPTOR) IMMUNOGLOBULIN G1 (CHIMERIC HUMAN-MUS MUSCULUS) FUSED ON BOTH HEAVY CHAINS (1-443, 1''- 443'') TO SERYL-SERYL (444-445, 444''-445'')-HUMAN ALFA-L-IDURONIDASE (IUDA) ((1-626) NATURAL VARIANT GLN6 (H452>Q)) (447-1072, 447''- 1072''), PRODUCED IN CHINESE HAMSTER OVARY (CHO) CELLS, GLYCOFORM ALFA: GAMMA1 HEAVY CHAIN FUSED TO IDUA (1-1072) [MUS MUSCULUS VH (IGHV1S56*01 (91.8%) -(IGHD) -IGHJ3*01 (93.3%)) [8.8.6] (1-113) -HOMO SAPIENS IGHG1*01, G1M17,1 (CH1 K120 (210) (114- 211), HINGE (212-226), CH2 (227-336), CH3 D12 (352), L14 (354) (337-441), CHS K2>S (443) (442-443)) (114-443) -2-MER DISERYL LINKER (444-445) -HOMO SAPIENS IDUA, CATALYTIC GLUTAMATES E182 (601), E299 (718) (446-1072)], (216-214')-DISULFIDE WITH KAPPA LIGHT CHAIN (1'-214') [MUS MUSCULUS V-KAPPA (IGKV9-120*01 (94.7%) -IGKJ1*01 (91.7%), L9>M (104)) [6.3.9] (1'-107') -HOMO SAPIENS IGKC*01, KM3 A45.1 (153), V101 (191) (108'-214')]; DIMER (222-222'':225-225'')-BISDISULFIDE. RECOMMENDED INN: LIST 80(WHO)
VALANAFUSPUM ALFA(INN)