(INNS)
ZABILUGEN ALMADENOREPVEK(INNC)
RECOMBINANT, REPLICATION-COMPETENT ONCOLYTIC HUMAN ADENOVIRUS TYPE 5 (AD5) VECTOR, ENCODING HUMAN HYALURONIDASE PH-20 (SPERM ADHESION MOLECULE 1 [SPAM1] SOLUBLE FORM), UNDER THE CONTROL OF THE ADENOVIRUS MAJOR LATE PROMOTER VIA INSERTION OF THE PIIIA SPLICE ACCEPTOR AND A KOZAK SEQUENCE. GENETIC MODIFICATIONS OF THE VIRAL GENOME ALSO INCLUDE THE INSERTION OF FOUR E2F-RESPONSIVE SITES ALONG WITH ONE EXTRA SP-1 TRANSCRIPTION FACTOR BINDING SITE TO CONTROL EXPRESSION OF THE VIRAL EARLY REGION 1A (E1A) GENE, A 24 BASE PAIR DELETION IN THE E1A GENE, AND THE REPLACEMENT OF THE KKTK DOMAIN OF THE FIBER SHAFT WITH AN INTEGRIN-BINDING, TUMOUR-SELECTIVE RGDK MOTIF(WHO)
ZABILUGENUM ALMADENOREPVECUM(INN)