(INND)
ZEDENOLEUCEL(INNC)
ALLOGENEIC MULTI-TUMOUR ASSOCIATED ANTIGEN SPECIFIC T LYMPHOCYTES PREPARED FROM PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMCS), COLLECTED BY APHERESIS FROM HUMAN LEUKOCYTE ANTIGEN (HLA)-MATCHED DONORS. THE DONOR T CELLS ARE PURIFIED BY DEPLETING CD14+ AND CD56+ CELLS, THEN CO-CULTURED EX VIVO WITH ANTIGEN PRESENTING DENDRITIC CELLS, DERIVED FROM THE SAME DONOR THAT HAVE BEEN EXPOSED TO A PEPTIDE MIXTURE OF FOUR TUMOUR ASSOCIATED ANTIGENS: PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA (PRAME), CANCER/TESTIS ANTIGEN 1 (LAGE2, NY-ESO-1), SURVIVIN (BIRC5) AND WILM'S TUMOR PROTEIN (WT1). THE CELLS ARE EXPANDED IN MEDIUM CONTAINING RECOMBINANT CYTOKINES INTERLEUKIN 6 (IL-6), 7 (IL-7), 12 (IL-12), AND 15 (IL-15). CELLS CONSIST OF A MIXTURE OF CD4+ AND CD8+ T CELLS, THAT INCLUDE EFFECTOR MEMORY (CD45RA-CD197-; ON AVERAGE 30%), CENTRAL MEMORY (CD45RA-CD197+; ON AVERAGE 43%), NAIVE (CD45RA+CD197+; ON AVERAGE 22%) AND TERMINALLY-DIFFERENTIATED EFFECTOR MEMORY (CD45RA+CD197-; ON AVERAGE 5%) T CELLS(WHO)
ZEDENOLEUCELUM(INN)