(INNS)
ZUNIBERGEN ROKPARVOVEK(INNC)
RECOMBINANT NON-REPLICATING ADENO-ASSOCIATED VIRUS (AAV) VECTOR WITH A RETINA-SPECIFIC CAPSID VARIANT, ENCODING A MICRORNA (MIRNA) TARGETING EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH FACTOR C (VEGF-C) AND A CODONOPTIMISED FUSION PROTEIN THAT CONSISTS OF VEGF-BINDING REGIONS DERIVED FROM THE EXTRACELLULAR DOMAINS OF HUMAN VEGF RECEPTORS 1 AND 2 FUSED TO THE FC PORTION OF HUMAN IMMUNOGLOBULIN G1 (THE MATURE EXPRESSED PROTEIN IS EQUIVALENT TO AFLIBERCEPT), UNDER CONTROL OF A SYNTHETIC CAG PROMOTER AND THE SIMIAN VIRUS 40 POLYADENYLATION SEQUENCE, FLANKED BY AAV2 INVERTED TERMINAL REPEATS. THE VEGF-C TARGETING MIRNA SEQUENCE IS LOCATED WITHIN THE CHICKEN BETA-ACTIN INTRON OF THE CAG PROMOTER(WHO)
ZUNIBERGENUM ROCPARVOVECUM(INN)